List of Presentations and Sessions Highlighting Transplant Research

Saturday, June 4, 2022

In-Depth Symposia: Optimizing Donor / Recipient Matching to Increase LDLT

  • Presenter:  Giuliano Testa, MD, MBA, FACS

  • Time/Location:  11:10am-11:20am EST – Location TBA


Oral Abstract: A Randomized Phase 2 Study Of Mau868 Vs Placebo To Treat Bk Viremia In Kidney Transplant Recipients

  • Presenter:  Bernard Fischbach, MD, CCRP

  • Time/Location:  2:30pm-2:40pm EST - Hynes Ballroom B

  • Abstract/Study Purpose:  To assess the safety and efficacy of MAU868, a BK virus-specific monoclonal antibody, in adult kidney transplant recipients with BK viremia.

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Poster Abstract: Increased Use of DCD Liver Grafts Does Not Adversely Affect Outcomes: A Single-center Experience

  • Presenter:  Michele Finotti, MD

  • Time/Location:  5:30 PM - 7:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose:  Donation after circulatory death (DCD) donors are underutilized in liver transplantation (LT), partly due to fear of inferior outcomes. Our center has evolved from a low- to high-DCD liver utilization program. We hypothesized that there would be a difference in donor and recipient characteristics as well as recipient outcomes between high and low DCD utilization eras.

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Poster Abstract: Evolution of Donation after Circulatory Death Liver Transplantation in the United States

  • Presenter:  Michele Finotti, MD

  • Time/Location:  5:30 PM - 7:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose:  With the shortage of organs for liver transplantation (LT), different solutions have been proposed to expand the donor pool: utilization of extended criteria organs, living donation, machine perfusion and donation after circulatory death (DCD) organs. The aim of this study is to evaluate the trend of DCD liver graft utilization in the last decade in the U.S. and determine the impact of increased DCD LT if all centers utilize these organs.

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Poster Abstract: A Successful Expansion of Donor Liver Supply Is Feasible With the Selective Use of Older DCD Livers

  • Author:  Greg McKenna, MD, FRSC(C), FACS

  • Time/Location: 5:30 PM - 7:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose:  DCD are a key way to expand the donor pool, yet many centers are hesitant about using anything but the most favorable DCD allografts, given the lack of data regarding older donors. Expanding to older DCD donors >50 years may be an untapped potential option to increase donor liver supply.

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Poster Abstract: An In Depth Assessment of Unsuccessful DCD Donor Procurement Attempts: Areas for Improvement

  • Author:  Greg McKenna, MD, FRSC(C), FACS

  • Time/Location:  5:30 PM - 7:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose:  DCD donors are a key way to expand allograft supply but an aggressive strategy of pursuing DCD liver allografts is associated with significant number of unsuccessful donor procurements. Understanding the elements in unsuccessful DCD can allow more efficient decisions, and maximize DCD procurements.

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Poster Abstract: Liver and Kidney Transplantation From Donation After Circulatory Death Heart Donors In the US: Better Early Outcomes with Normothermic Regional Perfusion versus Cold Flush

  • Author:  Matt Rosenzweig, DO

  • Time/Location:  5:30 PM - 7:00 PM EST - Hynes Hall C

  • Abstract/Study Purpose:  Donation after circulatory death (DCD) heart donation is increasingly common in the US. The two methods for DCD heart donation are normothermic regional perfusion (TA-NRP) and cold flush with ex-vivo heart machine perfusion (CF-MP). Liver and kidney transplant outcomes after TA-NRP DCD have shown promise outside the US but have not been reported in the US.

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Poster Abstract: Early Outcomes of Kidney Transplant Recipients from Donors with Severe SARS COV 2 Pneumonia

  • Author:  Matt Rosenzweig, DO

  • Time/Location:  5:30 PM - 7:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose:  Transplantation of kidneys from donors with active SARS-CoV-2 infection is uncommon due to concerns about the risk of viral transmission and kidney quality. To date, there is no conclusive data that viral transmission from extra-pulmonary solid organ transplant is a possibility. Given the prevalence of SARS-CoV-2 infections in potential donors, the shortage of kidneys available for transplantation and the low risk of viral transmission, we developed a clinical protocol for accepting kidneys from donors with active SARS-CoV-2 infection and preserved kidney function.

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Sunday, June 5, 2022

IMPACT Debate: Donor-Derived Cell Free - DNA – Thinking Outside of the Box: Lessons to be Learned, Pro: Out with the Old, In with the New! Histopathology is so 1980s!

  • Author:  Shelley Hall, MD, FACC, FHFSA, FAST

  • Time/Location:  7:10 AM- 7:20 AM EST


Oral Abstract: Outcomes of a Standardized Antibody-Mediated Rejection (AMR) Treatment Protocol in Heart Transplant Recipients (HTR)

  • Author: Jenny Lee, PharmD

  • Time/Location: 6:00 PM EST - Hynes Room 210

  • Abstract/Study Purpose: AMR in HTR portends poor clinical outcomes. Reported mortality range between 20-50%, with higher rates reported for late AMR occurring at least 1 year after HT. Optimal AMR treatment in HTR is unknown and impact of treatment on long-term outcomes remains limited. We examined the AMR treatment outcomes in HTR using our institution’s standardized treatment protocol after implementation in January 2016.

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Poster Abstract: Does ABO/HLA Matching Matter In Uterus Transplantation

  • Author:  Liza Johannesson, MD, PhD

  • Time/Location: 7:00 PM - 8:00 PM EST – Hynes Hall C & D

  • Abstract/Study Purpose: Uterus transplantation (UTx) is the most commonly performed vascular composite allograft and is rapidly becoming an accepted treatment for absolute uterine-factor infertility (AUFI). There is little known of how ABO/HLA -donor/recipient compatibility affects UTx transplant outcome. This study aimed to assess the importance of ABO/HLA-donor/recipient compatibility in relation to rejection, graft survival and live birth rate.

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Poster Abstract: Prospective Analysis of the Impact of Impella 5.5 Devices on HLA Antibody Development in Transplant Recipients

  • Author:  Karen Castro, Clinical Research Coordinator

  • Time/Location: 7:00 PM- 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Little is known about the development of Human Leukocyte Antigen antibodies with the use of the new Impella 5.5 temporary mechanical circulatory assist device.

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Poster Abstract: Impact of Cytomegalovirus Infection on mRNA Expression Utilizing the Molecular Microscope in Heart Transplant Recipients

  • Author:  Srikant Patlolla, MD

  • Time/Location:  7:00 PM- 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Little is known about the development of Human Leukocyte Antigen antibodies with the use of the new Impella 5.5 temporary mechanical circulatory assist device.

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Poster Abstract: A Real-world Analysis with the Molecular Microscope Diagnostic System in Dual-organ Transplant Recipients

  • Author:  James Blair, MD

  • Time/Location:  7:00 PM- 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: The Molecular Microscope Diagnostic System (MMDx) analyzes ribonucleic acid transcripts to provide sophisticated differentiation amongst T-cell mediated rejection (TCMR), antibody mediated rejection (AMR), injury and healthy tissue. However, little is known about its performance in dual organ transplant recipients.

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Poster Abstract: Biological Functions of Circulating miRNAs in Patients with Chronic Pancreatitis Undergoing Total Pancreatectomy with Islet Autotransplantation

  • Authors:  S. Vasu, C. Darden, Y. Liu, M. Lawrence, B. Naziruddin

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Our previous reports showed that in patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel of 12 miRNAs (hsa-miR-375, hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-216a-5p, hsa-miR-7-5p, hsa-miR-221-3p, hsa-miR-320d, hsa-miR-122-5p, hsa-miR-200c-3p, hsa-let-7e-5p, hsa-miR-125b-5p, hsa-miR-99b-5p) to assess whether these miRNAs exert important biological functions in pancreas in the context of CP.

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Poster Abstract: Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation

  • Authors:  S. Vasu, C. Darden, J. Mattke, Y. Liu, M. C. Lawrence, B. Naziruddin

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo after human-to-mouse xenoislet transplantation. Islet antigens including insulin, glutamic acid decarboxylase 65 (GAD65), Zinc Transporter 8 (ZnT8) induce autoimmunity in Type 1 Diabetes (T1D). In the context of islet auto- or allo-transplantation, we hypothesize that islet-derived exosomes may carry self-antigens resulting in induction of immune (auto- or allo-) responses, further contributing to islet graft rejection.

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Poster Abstract: Evidence for Improved Quality of Life Among Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation Using EORTC QLQ-C30 and QLQ-PAN 26

  • Authors:  M. Coluzzi, B. Naziruddin, G. Saracino, G. Testa, E. Beecherl, N. Onaca

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is the treatment of choice to preserve endocrine function, alleviate pain, reduce or eliminate chronic narcotic use and improve a very poor-quality life when other strategies were not effective in chronic pancreatitis. We reviewed Quality of Life using a large cohort of TPIAT patients at our center.

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Poster Abstract: Spleen-Preserving Total Pancreatectomy with Islet Autotransplantation with Complete Preservation of the Splenic Arterial and Venous Supply Does Not Impact Islet Yield and Function

  • Authors:  M. Coluzzi, B. Naziruddin, G. Saracino, G. Testa, E. Beecherl, N. Onaca

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Typically, Total Pancreatectomy with Islet Autotransplantation (TPIAT) includes splenectomy. Spleen sparing TPIAT was described in the literature using the Warshaw technique, with proximal ligation of the splenic artery, which can cause splenic infarcts. We hereby report spleen sparing TPIAT with preservation of the splenic artery and vein (SPTP), thus with full preservation of the blood supply to the spleen and improved blood supply to the greater curvature of the stomach.

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Poster Abstract: Association of Circulating microRNAs with Fibrosis and Metabolic Outcomes in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation

  • Authors: S. Vasu, G. Saracino, Y. Liu, J. Mattke, C. Darden, M. C. Lawrence, B. Naziruddin

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: In patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel of 12 miRNAs (hsa-miR-375, hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-216a-5p, hsa-miR-7-5p, hsa-miR-221-3p, hsa-miR-320d, hsa-miR-122-5p, hsa-miR-200c-3p, hsa-let-7e-5p, hsa-miR-125b-5p, hsa-miR-99b-5p) for further analysis of associations with fibrosis and metabolic outcomes after TPIAT.

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Poster Abstract: Clinical Outcomes In A Large Transplant Cohort Hospitalized With COVID-19: Mycophenolate Mofetil (MMF) Utilization And Mortality Trends

  • Author:  Robert Gottlieb, MD, PhD, FACC

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: To characterize demographics, treatment patterns, and outcomes among 3,998 transplant patients hospitalized for COVID-19 over 16 months of the pandemic (May ’20-Aug ’21).

  • For More Information: Click Here


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Monday, June 6, 2022

IMPACT Session: “I Don’t Want My Patients’ Kidneys to Fail!”: Rationale and Clinical Scenarios in Which Biomarkers Could Help Guide Immunosuppression Optimization in Liver Transplantation

  • Presenter:  Sumeet Asrani, MD, MSc

  • Time/Location:  7:20 AM – 7:30 AM EST – TBA


Oral Abstract: Impact Of Donor and Recipient Characteristics on Early Post-transplant Donor derived Cell-free DNA (dd-cfDNA) Scores

  • Author:  Amit Alam, MD

  • Time/Location:  3:50 PM EST - Hynes Room 210

  • Abstract/Study Purpose: Dd-cfDNA (AlloSure, CareDx; Brisbane, CA) has been demonstrated to detect allograft injury after heart transplantation in a large and diverse patient cohort in the United States; however, little is known about the association between donor and recipient demographic characteristics and dd-cfDNA results in the early post-transplant period.

  • For More Information: Click Here


Oral Abstract: The Feasibility Of Changing HCC MELD Exception Criteria To An Exclusive DCD-Only Option: A Strategy To Increase DCD Utilization

  • Author:  Greg McKenna, MD, FRSC(C), FACS

  • Time/Location:  4:40 PM EST - Hynes Room 312

  • Abstract/Study Purpose: Outcomes of DCD liver transplantation is comparable to DBD but routine utilization of DCD liver grafts is surprisingly uneven in the US. A more uniform and broader utilization of DCD liver grafts would significantly ease supply-demand pressure. The greatest benefit would be seen for HCC patients. We propose a new HCC Exception Criteria system where priority points would only be allocated for the use of DCD liver allografts. The implementation of such system would nudge transplant centers toward the utilization of DCD liver grafts. This study assesses whether the present supply of DCD liver grafts would match the new demand of the proposal.

  • For More Information: Click Here


Oral Abstract: Comparative Analysis of Liver Organ Offers Pre- And Post- Acuity Circle Policy Change In The Us

  • Author:  Anji Wall, MD, PhD

  • Time/Location:  4:40 PM EST - Hynes Room 311

  • Abstract/Study Purpose: With the intended goal of reducing geographic inequities, the United Network for Organ Sharing (UNOS) and Organ Procurement and Transplantation Network (OPTN) transitioned to an Acuity Circles model (AC) of organ allocation for liver transplantation. The consequences are a more complex system of organ allocation and distribution that will especially increase the number of connections between different OPOs and transplant centers. At our center, we have found an increase in the number of liver offers per month without an increase in liver transplants. Given the increase in complexity of network connections for liver allocation and increased pressure on OPOs to allocate organs, we hypothesized that the total number of liver offers have increased post-AC policy change in the US.

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Poster Abstract: Variation Exists In Hospital Policies for Donation after Circulatory Death within a Single Donor Service Area

  • Author:  Rehma Shabbir

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: The Joint Commission mandates that all hospitals have a donation after circulatory death (DCD) policy. Previous studies have demonstrated variability in DCD policy elements. With the increasing utilization of DCD donors, we hypothesized that there would be more consistency among DCD policies.

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Poster Abstract: The Higher Cost Of Donation after Circulatory Death Liver Transplantation Starts with Acquisition Costs: a Single Center Comparison Liver Acquisition Fees by Donor Type

  • Author:  Anji Wall, MD, PhD

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Donation after circulatory death (DCD) donors are an increasing proportion of deceased donor population in the US. One drawback of DCD donors is that many don’t expire in time for organ donation resulting in dry runs. We hypothesized that not only do DCDs increase the time spent by transplant surgeons in the acquisition of organs but they also have higher acquisition costs per transplanted liver.

  • For More Information: Click Here


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Tuesday, June 7, 2022

IMPACT Liver Session: Personalized Management of Cardiovascular Disease in Liver Transplant Recipients

  • Moderator:  Shelley Hall, MD, FACC, FHFSA, FAST

  • Time/Location:  7:00 - 8:00 AM EST


IMPACT Psychosocial & Ethics Session: Ethical Dilemmas

  • Moderator:  Shelley Hall, MD, FACC, FHFSA, FAST

  • Time/Location:  10:00 - 11:00 AM EST


Oral Abstract: Donors’ Perceptions of Uterus Donation Motivations, Informed Consent and Value: A Qualitative Study Of Dallas Uterus Transplant Study (DUETS) Participants

  • Author:  Anji Wall, MD, PhD

  • Time/Location:  4:10 PM EST - Hynes Room 313

  • Abstract/Study Purpose: Clinical trials have demonstrated the feasibility and reproducibility of uterus transplantation (UTx) to treat absolute uterine factor infertility. Successful live births have resulted from both deceased and living donor uterus transplantation, with more successful recipient pregnancies after living uterus donation. The utilization of living uterus donors for this quality of life-enhancing transplantation remain controversial because of the risks that living uterus donation entails. This study aimed to assess the perceptions of living uterus donors regarding their motivations for donation, perceptions of informed consent, and the value of the uterus donation experience.

  • For More Information: Click Here


Oral Abstract: Living Donor Robotic Hysterectomy Provides Excellent Outcomes in Uterus Transplant Recipients

  • Author: Liza Johannesson, MD, PhD

  • Time/Location:  4:50 PM EST - Hynes Room 313

  • Abstract/Study Purpose: Living donor (LD) hysterectomy for Uterus Transplantation (UTx) can be performed robotically with vaginal extraction of the graft. There are no reports of the technical or functional outcomes of robotically procured grafts (RPG). This study reports outcomes from the largest series of UTx performed with RPG.

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Oral Abstract: National Consortium Registry Insights on Management and Outcome of Hepatitis C Viremic Heart Transplants

  • Author:  Mahmoud Salem, MD

  • Time/Location:  6:10 PM EST - Hynes Room 312

  • Abstract/Study Purpose: Multicenter US registry of clinical management of HCV NAT+ hearts.

  • For More Information: Click Here


Oral Abstract: Impact of a Transplant Pharmacy Collaborative Practice Agreement Implementation on an Institutional Medication Assistance Program Funding Utilization

  • Author:  Ann Kataria, PharmD, BCPS

  • Time/Location:  6:20 PM EST - Hynes Room 206

  • Abstract/Study Purpose: Post-transplant medication cost can pose a significant barrier for patient adherence and graft outcomes. Strategic selection of medication agent is often challenging and requires considerations for clinical needs, insurance coverage, and affordability. A pharmacy collaborative practice agreement (CPA) allows pharmacists to provide clinical services under supervising physicians, including therapeutic interchanges and alternative therapy recommendations. We sought to assess the impact of a pharmacy CPA on an institutional foundation’s Medication Assistance Program (MAP) funding utilization in a post-abdominal transplant ambulatory clinic.

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Poster Abstract: Effect of Sars-CoV-2 Delta Variant on Post-Vaccination Covid-19 Infection in Solid Organ Transplant Recipients

  • Author:  Erin Tuttle, MD

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: In July 2021, the SARS-CoV-2 Delta variant emerged as the dominant strain in the North Texas area. We reviewed COVID-19 infections post-vaccination in Solid Organ Transplant Recipients (SOTRs) before and after the Delta variant became the dominant strain.

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Poster Abstract: Safety and Efficacy of Darbepoetin Alfa Dosing Strategies in Renal Transplant Recipients

  • Author:  J. A. Solis, PharmD

  • Time/Location:7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Post-transplant anemia (PTA) is a common phenomenon in renal transplant recipients (RTR). There are currently no consensus guidelines for PTA, however patients are commonly treated with erythropoiesis-stimulating agents such as darbepoetin alfa (DA). While previous studies have shown the efficacy of DA in RTR with PTA, optimal dosing remains controversial. The purpose of this study is to evaluate two dosing strategies for DA in RTR with PTA.

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Poster Abstract: Assessing Proportion of Days Covered (PDC) of Mycophenolate (MCP) Prescriptions in Post Kidney Transplant (KT) Recipients as a Predictor of Clinical Outcomes

  • Author:  K. Sandlin

  • Time/Location:  7:00 PM - 8:00 PM EST - Hynes Halls C & D

  • Abstract/Study Purpose: Nonadherence to medications following KT is a risk factor for adverse outcomes. PDC is an objective measure of adherence obtained through retail prescription records and is calculated by the number of days covered by a medication in a specified time period. An 80% cut-off has been reported in the literature as a threshold that stratifies adherent and non-adherent patients. The aim of this study was to assess the impact of adherence as described by PDC of MCP on post-KT outcomes.

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Wednesday, June 8, 2022

Plenary Session: A Single Center Analysis of Organ Offers and Workload for Liver and Kidney Allocation

  • Author:  Vik Reddy

  • Time/Location:  8:30 AM EST - Hynes Veterans Auditorium

  • Abstract/Study Purpose: UNOS/OPTN transitioned to Acuity Circles allocation for kidneys and livers which has increased the complexity of the network of organ procurement organizations (OPOs) and transplant centers. Moreover, there is increased pressure on OPOs to allocate organs. In this study, we hypothesized that allocation changes and regulatory pressure have increased organ offers and program workload.

  • For More Information: Click Here